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The IBD trials cited in this literature (PL14736) reported no toxicity and no lethal dose reached, which is a meaningfully strong safety signal, but the bulk of the mechanistic evidence remains preclinical

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Answer: Semax is thought to work largely by stimulating brain-derived neurotrophic factor (BDNF), a protein that supports the growth, survival, and plasticity of neurons, while also influencing neurotransmitters tied to focus and mood

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