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These changes were accompanied by marked downregulation of junctional proteins zonula occludens-1 (ZO-1), E−cadherin, and occludin ( in vitro findings link ferroptotic signaling to impaired intercellular adhesion and increased epithelial permeability, suggesting a plausible mechanism for enhanced bacterial translocation into deeper periodontal tissues in vivo
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Recent research has reported that some drugs in combination with antibiotics have displayed synergistic killing against resistant bacteria ( Escherichia coli , and L-alanine metabolism conferred aminoglycoside resistance via Na + -NQR ( Glutathione (GSH) is an antioxidant synthesized in most Gram-negative bacteria and a few Gram-positive bacteria ( Escherichia coli by neutralizing antibiotic-induced oxidative stress, increasing the efflux of antibiotics, and promoting acid shock survival ( However, it is not known whether GSH can restore the activity of meropenem against CRKP
