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Effect of ovarian steroids Variations in E2 and P4 influence carbohydrate and lipid metabolism through coordinated effects on insulin sensitivity, glucose transport (e.g., GLUT4 translocation), hepatic glucose output, lipolysis, fatty acid oxidation, and mitochondrial efficiency [8,42,43,44,45,46]

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Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase