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This has led to the development of various binders, 71,72 including the carbazole PK083 (ΔT m = 0.8 °C at 125 μM PK083), 65 the iodophenole PK5176 (ΔT m = 2.6 °C at 250 μM PK5176), 71,73 (the aminobenzothiazole MB710 (ΔT m = 2.0 °C at 250 μM MB710), 74 and the potent clinical candidate PC14586 (Rezatapopt)