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The first of these involves the reduction of the disulfide bond and concurrent liberation of diethyldithiocarbamate (DDTC), an inhibitor of ALDH in vivo but not in vitro (Deitrich and Erwin, 1971
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The Fenton-like reaction, on the other hand, extends its reaction conditions to other metal ions (Cu 2+ , Ca 2+ , Zn 2+ ) and oxidizing agents (e.g., peroxy groups) to produce peroxide ions (•OO-), hydroxyl radicals (•OH), etc (Tang et al., 2021b)