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It has been demonstrated by in vivo or in vitro methods and by the functional genomics of XMEs and neurodegenerative diseases that PD and motor neuron disease (MND) can be associated with problems in xenobiotic metabolism
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In the retina and other ocular tissues, dysregulated DIOs expression may alter key processes such as angiogenesis and oxidative stress adaptation, underscoring the importance of DIOs-mediated local TH signaling in both physiological and pathological ocular conditions
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