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The primary antibodies and their corresponding secondary antibodies used are listed in the table below: Statistical analysis All analyses in this study were calculated using Graphpad Prism, and the data were presented as mean ± SD

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1 Introduction Interleukin 1 (IL-1), a critical proinflammatory cytokine produced by monocytes and macrophages, comprises two distinct ligands: interleukin 1α (IL-1α) and interleukin 1β (IL-1β) ( In 2001, the U.S