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Regarding the comment on how geographic area assignments would work for providers performing services under multiple TINs with the same ZIP Code, we would treat each TIN and NPI combination as separate entities to which we would assign a geographic area

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Based on these studies, elevated C2, C3-DC, C4, or C5 imply impaired metabolism of BCAAs and/or metabolic inflexibility, therefore, supporting their use as potential early biomarkers of the onset of PRIS that could be incorporating into a therapeutic monitoring strategy for propofol [97,98,99,131]