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Similarly, a randomized, double-blind, placebo-controlled study demonstrated that the administration of 1500 mg of curcumin for 8 weeks, in conjunction with pharmacological therapy, resulted in improved clinical parameters and reduced levels of CRP and erythrocyte sedimentation rate in patients with mild to moderate ulcerative colitis (UC), without any changes in TNF-α levels (Sadeghi et al., 2020)