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In our hands, overexpression of mGluR3 was observed in the progression of cirrhosis to hepatocarcinoma development in rats and in HepG2 cell line, suggesting a role in the pathophysiology of the liver cancer (A.C

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For example, while Gln and the Gln-Glu cycle are believed to regulate Glu, an increased cycle turnover could mitigate excessive glutamatergic activity and maintain a balanced excitatory tone [15, 61]