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Peptides: Understanding the Hype Behind this Wellness Powerhouse

The TJs in the BBB vasculature, largely prevents paracellular diffusion into the brain spaces, leaving only the transcellular pathways by which a compound could enter or distribute into the brain

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Even during the preparation and dissolution process of nanosuspension, insoluble precipitates are formed due to the intermolecular electrostatic interactions between partially ionizable anionic drugs and oppositely charged surfactants, which lead to the low drug content, increased particle size, the formation of rough and irregular crystals, and decreased dissolution [59]