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Furthermore, the more recent observational data suggesting that the combination of high folate and low vitamin B-12 is associated with the worsening of both clinical outcomes and elevations in functional biomarkers of vitamin B-12 (23, 40, 41) imply that depletion of holoTC is attained even without stimulating hematopoiesis

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Inhibitors that prevent activin receptor IIB activation and myostatin-binding proteins (e.g., follistatin) fall under WADA's expanded interpretation