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Supporting information Acknowledgments The authors would like to acknowledge Hequn Song and Jia Liu from Xuzhou Medical University for some literature collection for the original manuscript

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To address these challenges, DDP-based combination regimens such as AP (doxorubicin and DDP) and MAP (high-dose methotrexate, doxorubicin and DDP) have emerged as the primary chemotherapy strategies employed in the treatment of OS