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The neurotoxicity of 5- S -cysteinyl catecholamines may be due to their further oxidation to benzothiazine species, such as DHBT-1 (dihydrobenzothiazine-1-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2 H -1,4-benzothiazine-3-carboxylic acid) (Shen et al., 1996, Shen et al., 1997, Vauzour et al., 2008)