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For those with chronic conditions or severe nutrient deficiencies, more frequent sessions may be necessary at the onset, and they may become less frequent over time as patients begin to enjoy the health improvements

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More recently, nilvadipine-a 1,4-DHP derivative-has successfully completed Phase III clinical trials for Alzheimer’s disease (NCT02017340), further validating the scaffold’s CNS permeability and long-term tolerability 25 .To the best of our knowledge, this study represents one of the first systematic evaluations of tetrahydropyridine derivatives as potential trypanothione reductase inhibitors in the context of antileishmanial drug discovery