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Key examples of research that suggest that this approach will be beneficial are that involving hepatocarcinoma, in which targeting the underlying liver fibrosis can increase efficacy of chemotherapy (Friedman et al., 2000), breast cancer, in which fibrotic breast disease predisposes individuals to cancer (Jacobs et al., 1999), and situations in which environmentally induced lung fibrosis can increase the incidence of lung cancer (Mossman and Churg, 1998)