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doi: 10.2174/1573397113666170321120329

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Thus, uncontrolled melanogenesis in the melanosome or outside (through autooxidation of its soluble metabolites), via depletion of major cell antioxidants and generation of ROS, and the direct action of quinone and semiquinone intermediates on RNA, DNA, and regulatory proteins will generate pro-mutagenic environment contributing to melanomagenesis ( Figure 2 )