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Ca 2+ channels aid iron cardiotoxicity by providing a major entry route for Fe 2+ ions into cardiomyocytes ( 2+ channel blockers as an adjunct therapy to iron chelators have been started ( 2+ channel blocker mainly used to treat hypertension ( In this study, we report two cases of hemochromatosis (primary and secondary) managed by the L-type Ca 2+ channel blocker (amlodipine) and compare them to the animal model of iron overload treated with amlodipine