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This is followed by phase II conjugation reactions involving glucuronidation by uridine 5′-diphosphoglucuronosyltransferases (including UGT1A1, UGT2B7, UGT1A9 and UGT2B4) and ultimately biliary excretion of the resultant glucuronides and reactive metabolites by ABCC2 efflux transporters expressed on the apical canalicular membranes of hepatocytes and renal tubular epithelial cells [38], [39], [40]

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