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In unstimulated cells or under normal physiological conditions, the NF-κB dimers are bound to inhibitory molecules of the IκB family of proteins (inhibitors of NF-κB), and the activation of NF-κB requires cleavage from IκB by IκB kinase (IKK)

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Joint injections are a proven treatment option for patients with osteoarthritis, rheumatoid arthritis, bursitis, gout, and other inflammatory joint disorders

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