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This process is linked to premature activation of the ROS/NF-κB signaling pathway and the resultant dysfunction of mitophagy in microglia derived from C57BL/6 J mice (Zhou et al., 2022)

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Interestingly, nanopore sequencing can also extract epigenetic status of the nucleotides (including both 5-Methylcytosine and 5-hydroxyMethylcytosine), and a large variety of bioinformatic tools have been developed for improving its detection properties