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A substantial disruption of elastin lamellae was observed (3.4-fold increase in number of breaks per section, Figure 2, G and H) and minimal fibrosis (Supplemental Figure 4D), while irregular VSMC morphology accompanied a shift toward expression of synthetic markers (Figure 2, I and J

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Figure 4 , on the left side, shows a simplified pathway from purines to uric acid, and on the right shows how medications for gout work, which is discussed further in sections 5 and 6 below ( Figure 4: Pathway from Purines to Uric Acid )