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In addition, Fer-1 alleviated DN and ameliorated renal hypertrophy and albuminuria by inhibiting ferroptosis, and ultimately reduced the accumulation of intracranial lipid peroxides in diabetic mice through the HIF-1α/HO-1 pathway [242]
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While most ctDNA analyses in CSF have focused on detecting cancer‐associated mutations, the prevalence of epigenetic alterations in pediatric brain tumors suggests that analyzing epigenetic markers in CSF ctDNA could provide a precise and sensitive means of evaluating treatment response, disease progression, and recurrence in brain tumors
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