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After 25 minutes all rats were lying down, and all presented generalized convulsions, a status lasting the next 5 hours

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Similarly to colchicine, podophyllotoxin binds the colchicine site at the interface of α- and β-tubulin, inhibits the assembly of tubulin into microtubules, blocks the cell cycle in G2/M phase, and finally leads to mitosis arrest 57,58

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