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For instance, inhibition of MCT1 disrupts lactate homeostasis and impairs both glycolytic flux and GSH biosynthesis in MYC-driven cancer, resulting in reduced glucose uptake and depletion of ATP, NADPH and GSH (50)
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However, the high accumulation of NGAL in renal tissues suggests the need for cautious consideration when administering this compound to patients with renal impairment (Liu and Huang, 1988)
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