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Glutathione remedies the reactivity of ROS by donating an electron to the ROS, hence making it stable, and no longer harmful

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While numerous in vitro assays demonstrate the free radical scavenging activity of compounds like curcuminoids, resveratrol, cinnamic acids, lignans, and flavonoids, their relevance to in vivo conditions is limited due to the rapid reactivity and short lifespan of RONS