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In nature there is a constitutive internalization and re-entry of the TCR-CD3 complex to the cell surface

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This sequence of pathological alterations encompasses various mechanisms of cell death, including apoptosis, pyroptosis, ferroptosis, necrosis, and PANoptosis, which interrelate and exacerbate one another, forming a vicious cycle that may ultimately result in multi-organ failure and significant impairment of CNS (Iba et al., 2023