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In addition, to minimize the risks of infections or other complications, the infusion should be administered only by familiar and skilled personnel with the process
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160–162 For example, the discovery that binding of certain small molecules to the PDI hydrophobic patch interferes with reduction of the protein substrate insulin but enhances reduction of a fluorescent GSSG analog suggested that engaging the hydrophobic site triggers an allosteric switch enhancing PDI reductase activity
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