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Without human trials, every approach is an estimate

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Understanding the link between folate/B 12 status and depression in later life is important as depression is a risk factor for functional decline (Reference Sivertsen, Bjørkløf and Engedal21) , admission to residential care (Reference Lenze, Schulz and Martire22) and early mortality (Reference Onder, Liperoti and Soldato23)

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