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Three B vitamins are therefore essential for keeping homocysteine levels in check: Vitamin B12 (in the methionine synthase pathway) Folate (B9) (also in the methionine synthase pathway) Vitamin B6 (in the cystathionine beta-synthase pathway) When any of these three is low, the body cannot process homocysteine efficiently, and blood levels rise

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This binding triggers membrane pore formation, leading to cell lysis and death, leaving normal cells unaffected (Goldberg et al., 2010)