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For example, the M2 isoform of the pyruvate kinase, which is under the regulation of the hypoxia-inducible factor, enables redirecting glycolytic intermediates to other metabolic pathways and stimulates the increased transcriptional activity of the HIF factor by binding to the transactivation domain [42]
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Many of us are living with MTHFR mutations and are unaware of our MTHFR status, and a small number of us are taking advantage of knowing the MTHFR genes we have
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