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Oxidative stress and mitochondrial metabolism Oxidative stress generally has an adverse effect on the bioenergetic status of cells, with H 2 O 2 treatment decreasing ATP production in mouse lens epithelial cells (Spector et al., 2002), mouse lymphocytes (Hyslop et al., 1988), rat cardiomyocytes (Janero et al., 1994), and human erythrocytes (Tavazzi et al., 2000)