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In the presence of suboptimal concentrations of L-arginine or of the cofactor BH 4 , NOS is functionally ‘uncoupled’ and produces O 2 −• via one-electron reduction of molecular oxygen (41, 42)
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While the researchers found much that is illuminating in their data, they acknowledged in their paper that “further investigation through large, prospective studies is imperative to substantiate the therapeutic potential of NAC in this context.” This article was developed by the editorial staff in conjunction with experts in the field
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