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Developing biomarkers tailored to assess TH activity in the retina, cornea, sclera, and optic nerve would facilitate more accurate monitoring of therapy and mitigate the risks of overtreatment or adverse effects
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While an elevated ferritin level can indicate excess iron stores, it is important to remember that it’s also an acute phase reactant and thus has a significant false positive rate, particularly in patients with necroinflammatory liver disease (alcoholic liver disease, chronic hepatitis B and C, non-alcoholic fatty liver disease), lymphomas, and patients with other non-hepatic chronic inflammatory conditions
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