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In particular, glucose metabolism in human RBCs is essential for (a) ATP production, which is relevant for the plasma membrane and cytoskeleton properties, (b) maintenance of redox balance (NADPH/glutathione), (c) reduction of methaemoglobin to haemoglobin by NADH-reductase, and (d) production of 2,3-bisphosphoglycerate (2,3-BPG), which binds to haemoglobin and releases oxygen [7]