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FIGURE 3 3.1 Vascular tone and ECD Endothelial cells play a crucial role in maintaining vascular tone by precisely regulating the secretion of various vasoactive substances, such as endothelium-derived relaxing factors (EDRFs) and endothelium-derived contracting factors (EDCFs), to maintain the dynamic balance of blood vessels

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Given that whether fibrosis is a cause or a pathological manifestation of CKD is unclear and intervening in the progression of CKD by directly targeting the treatment of renal fibrosis requires further in-depth research, conservative antifibrotic treatments, such as the use of well-tolerated Chinese herbal medicines, may achieve the negative regulation of various kidney diseases in their initial phases (124)

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