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However, this extrapolation from one organ to another is questionable as the exposure levels, the phase I metabolic capacity to generate NAPQI, the phase II metabolic capacity to eliminate APAP, and potential adaptive mechanisms in response to an APAP-induced cellular stress are not well described in the CNS system

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It is connected to pathological inflammation and excessive release of the cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-xie18) [176]