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The metabolic reprogramming of DCs is shown in Fig
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It is unclear precisely how viruses regulate TCA metabolite hubs, but high-throughput metabolomic analysis reveals elevated plasma succinic acid in moderate and severe COVID-19 disease 57,69 , and administration of dimethyl itaconate (a derivative of itaconate) during influenza A virus infection in mice reduced pulmonary inflammation and improved survival 59
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