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Consequently, the plant species containing the mutation D27E in the GMP enzyme could produce higher AsA contents than other plant species that lack this mutation (Li et al., 2016) Figure 5 The first discovery of a protein acting as a negative regulator of gene-encoding enzymes of the L-galactose pathway for AsA biosynthesis was reported by Nessler’s research team in the late 2000s (Zhang et al., 2009)