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Mitochondria are the major site for ascorbate (AsA) synthesis, and ascorbate is transported through a proton-electrochemical gradient or facilitated diffusion to other cellular compartments (Gill and Tuteja, 2010)

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CLL cells had decreased sensitivity to the ROS inducing agents fludarabine and oxiplatin when co-cultured with BM stromal cells.9 Chemo-protection was derived from the generation and release of cysteine by stromal cells for uptake by CLL cells