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The potential therapeutic targets of AVPs are located either on the virus (e.g., E-protein and S-protein) to prohibit viral binding or host cells, particularly, those present on the cell surface (e.g., ACE2 and TMPRSS2)

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Numerous studies showed that Piezo1 is expressed in most mammals, and that it is widely expressed in various organs and tissues in humans, including the brain, lungs, gastrointestinal system, bladder, and bones (Cahalan et al., 2015