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In vitro studies demonstrated cytotoxic activity in HepG2 cells and human liver cells L-02, leading to cell death, and demonstrated in in vivo studies that flavokavain B is responsible for the potentiation of kava hepatotoxicity upon herb–drug interaction in C57BL/6 mice
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These findings collectively support the role of physical activity not only as a promoter of general health, but also as a modifiable factor for reducing PD incidence
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