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In contrast, sustained elevation of cellular ROS levels can lead to the upregulation of pro-apoptotic cytokines, including interleukin-1β (IL-1β), interleukin-18 (IL-18), and tumor necrosis factor-α (TNF-α), which promote hepatocyte apoptosis and necrosis [7]
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Types of nano-carriers used in antioxidant delivery The use of nano-carriers for antioxidants delivery has especially received increasing interest in the past years owing to increased bioavailability, sustained release and target delivery [17, 305]
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