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In an animal study, LIF knock-out mice showed decreased astrocyte and microglial cell activities compared to wild type mice.54 Various insults to the CNS may induce over-expression of LIF, which may lead to neurobehavioral abnormalities similar to schizophrenia.56 Additionally, LIF gene polymorphism is associated with susceptibility to schizophrenia and working memory deficit.57 Another cytokine, TNF-α, has an important role in neuronal activity in the CNS.5859 TNF-α is usually maintained at low level under normal physiological conditions.60 However, when the microenvironment in the CNS is altered by injuries such as physical head trauma, infection, and ischemic attack, TNF-α is activated by glial cells.6162 Interestingly, TNF-α has a pivotal role in mediating neurogenesis via its receptors, tumor necrosis factor receptor (TNFR)-1 and TNFR-2
