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Its C-terminus is composed of conserved domains, including the FAT domain (shared by the FRAP, ATM, and TRRAP proteins) and the FKBP12-rapamycin binding (FRB) domain, which facilitates binding of the FKBP12–rapamycin complex, the kinase catalytic domain, and the FATC domain located at the extreme C-terminus

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Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair