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Glutathione‐dependent reductive stress triggers mitochondrial oxidation and cytotoxicity - Zhang - 2012 - The FASEB Journal - Wiley Online Library

Table 2 systematically compares model systems and their limitations, highlighting the urgent need for human-relevant platforms such as cochlear organoids and induced pluripotent stem cell-derived hair cells

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However, redox homeostasis is conditioned by the magnitude and duration of exposure to free radicals, since constant exposure can have a serious impact on intracellular signals or genetic expression, resulting in irreversible pathological consequences (Rhee et al., 2003), since most reactions of the body are dependent on the redox state (Tan et al., 2018)