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L.SuravajhalaP.et al (2016)

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[7] [8] Diversity [edit] Two classes of thioredoxin reductase have evolved independently from a shared ancestor of the FAD/NAD(P)-binding domain superfamily (IPR036188): A high molecular weight (MW = ~55,000) type containing a selenocysteine residue in its active site has been identified in higher eukaryotes including humans