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The remaining circulating copper is mainly bound to albumin, α2-macroglobulin or, to a lesser extent, to low molecular weight compounds [13,14]

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The cytotoxicity of hydrogen peroxide primarily occurs through its ability to generate hydroxyl radical through metal-catalyzed reactions, such as the Fenton reaction (reaction 2) In biology it seems likely that this reaction is particularly important as part of the Haber-Weiss reaction, where iron (or copper) is maintained in a reduced form by superoxide and hence capable of catalyzing the formation of the hydroxyl radical from hydrogen peroxide (134)

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