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TRANSCEND trial: Approved treatments are lacking for acquired hypothalamic obesity. New research findings on the efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, are summarized in a Quick Take video: https://nej.md/4eVGFg9

B12 is a water-soluble vitamin found in meat, fish, and dairy products, and its deficiency can lead to nausea, weak muscles, fatigue, and numerous problems

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In a seminal study in diet-induced obese mice, 5-amino-1MQ administration led to a 35% reduction in mass and size, a 30% decrease in adipocyte size, and a 40% decrease in adipocyte volume in the rodents

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