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Additional molecular targets being investigated include MMPs, ADAMTS enzymes, and neurotrophic factors that contribute to pain amplification and extracellular matrix breakdown [10]

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Ciprofloxacin has been proven to increase the expression of MMP-3 [32] and MMP-2 [40] in human Achilles-tendon-derived cells, leading to reduced collagen synthesis through inhibition of tenocyte proliferation [32] as well as degradation of collagen type I